prodrug
释义
前药；
权威例句
Prodrug Strategies in Anticancer ChemotherapyA Water‐Soluble Prodrug of Taxol with Self‐Assembling Properties
FK228 (Depsipeptide) as a Natural Prodrug That Inhibits Class I Histone Deacetylases
Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2
Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device.
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity.
The Direct Thrombin Inhibitor Melagatran and Its Oral Prodrug H 376/95: Intestinal Absorption Properties, Biochemical and Pharmacody...
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles
Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-...
Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′...
1. Aim:To study the synthesis of ceftizoxime alapivoxil analogues and to search for new-type prodrug of ceftizoxime.
前言：目的：研究头孢唑肟丙匹酯类似物的合成，寻找新的头孢唑肟前药。
www.chemyq.com
2. Aim To synthesize acylated prodrug of tacrine hydrochloride (THA) to improve the infiltration ability across the blood brain barrier (BBB).
目的制备盐酸他克林（THA）的酰化前体药物以提高其透过血脑屏障（BBB）的能力。
dict.cnki.net
3. Fospropofol disodium, a water-soluble prodrug of propofol, is a new drug used in the diagnosis and sedative therapy.
磷丙泊福钠是丙泊酚的水溶性前体药物，是一种应用于诊断及治疗阶段的镇静催眠新药。
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4. Conclusions— Treatment with N-acetylcysteine, a safe prodrug against oxidation, reversed established cardiac phenotype in a transgenic rabbit model of human HCM.
结论：N-乙酰半胱氨酸作为抗氧化剂安全的药物前体，可以逆转肥厚性心肌病转基因模型兔的心肌表型。
www.mdchome.com
5. Prodrug is an effective way to improve the oral absorption of the drugs which belong to Biopharmaceuticals Classification System(BCS) class III and IV.
前药研究是提高生物药剂学分类系统中第III和IV类药物口服吸收的有效途径之一。
www.dictall.com
6. Every proton pump inhibitor so far developed is administered in a prodrug form.
迄今为止每个质子泵抑制剂都被研究开发为一个前药的管理形式。
blog.tianya.cn
7. AIM: To investigate the synthesis and colon targeted characteristics of pectin ketoprofen prodrug.
目的：合成果胶酮洛芬前药并进行体外评价。
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8. This review addresses the progress of the oral prodrugs in recent years, mainly including classical prodrug design and targeted prodrug design.
本文综述了近年来口服前药研究的进展，主要包括经典前药设计和靶向前药设计。
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9. Objective To determine the efficacy of adenovirus-mediated suicide gene transduction combined with prodrug 5-fluorocytosine (5FC) as a therapeutic protocol for pancreatic cancer.
目的探讨腺病毒介导自杀基因联合前药5FC对人胰腺癌的治疗作用。
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10. The prodrug exposed to strong acid is protonated and undergoes a conformational change to its active form which is capable of inhibiting the proton pump.
前药的接触了强酸后被质子化，并且经过结构的改变成为真正能够抑制质子泵的活化形式。
blog.tianya.cn
11. With the progress of gene therapy, the results of researches using strategies of transcriptional targeting and gene delivered enzyme-prodrug are exciting.
随着基因治疗研究的深入，转录靶向和酶解前体药策略成为肿瘤基因治疗的热点研究领域。
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12. Combined with ionization radiation and prodrug showed greater toxicity to yCDglyTK-expressing CNE-2 cells than disposed with ionization radiation or prodrug alone.
电离辐射与前药的联合大大增强了对自杀基因阳性CNE-2细胞的杀伤作用，其杀伤作用大于单独自杀基因前药系统和单独放射。
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13. The DDS were divided into prodrug and chemical delivery system, macromolecular carrier system, microparticulate carrier system, implantable polymer system and infusion pump.
药物传输系统分为前药系统、大分子载体给药系统、微粒给药系统和植入输注系统。
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14. Establish the method of High Performance Liquid Chromatographic(HPLC) for determination of Methylprednisolone (MP)and its ester prodrug Methylprednisolone Hemisuccinate (MPHS) in rat plasma.
为建立测定血浆中甲基强的松龙（MP）及其前体酯甲基强的松龙琥珀酸酯（MPHS）的高效液相色谱（HPLC）法。
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15. Conclusion The targeted expression of CD gene combined prodrug 5 FC may be a potential approach for gene therapy for human pancreatic carcinoma.
结论CD基因靶向性转导结合前体药5FC疗法，可能成为人胰腺癌基因治疗的新途径。
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16. The invention further provides the application of the liver targeting anticancer nanometer prodrug system basing on the dendritic polymer in the preparation of drugs for treating solid tumors.
本发明还提供了一种基于树形聚合物肝靶向抗癌纳米前药系统在制备治疗实体肿瘤药物中的应用。
ip.com
17. The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid, and risperidone, a metabolite, or a prodrug thereof.
所述可流动组合物包含可生物降解热塑性聚合物，有机液体和利培酮、其代谢物或前药。
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18. The compound or a suitable salt or prodrug thereof is useful for the treatment of individuals suffering from a cancer or another proliferative disorder or disease.
该化合物或其合适盐或前药适用于治疗患有癌症或另一增殖性病症或疾病的个体。
ip.com
19. The invention relates to a mutual prodrug and a preparation method thereof based on paclitaxel and nitrogen mustard.
本发明涉及一种基于紫杉醇-氮芥的协同前药及其制备方法。
ip.com
20. Mycophenolate mofetil, the prodrug of the 2-(4morpholino) ethyl ester of mycophenolic acid, has been widely applied to the prophylaxis of acute graft rejection in solid organ transplantation.
麦考酚吗乙酯是麦考酚酸的2-乙基酯前体药物，临床广泛应用于器官移植后的抗排斥治疗。
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21. CONCLUSION The prodrug of 4-Aminotetrahydroacridine can be synthesized by this method.
结论该法有助于他克林前体药物的研究。
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22. Preferably, the active drug is more than about 10 times as active as the prodrug.
优选地，活性药物 的活性比前体药物高约10倍以上。
ip.com
23. Gel permeation chromatography (GPC) was used to determine the molecular weight of the prodrug.
利用凝胶渗透色谱（GPC）测定了前药的分子量。
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24. GPI 15715 is the first water-soluble propofol prodrug that has been studied in humans.
GPI15715是第一个用于人体研究的水溶性异丙酚前体。
danci.911cha.com
25. Prodrug is a new drug delivery system based on polymer compounds.
大分子前药是以大分子化合物为载体的一种新的药物传输体系。
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26. In order to search new compounds with higher antitumor activities and lower toxicity, mutual prodrug of silatrane derivatives and 5-fluorouracil were designed on the basis of association principle.
杂氮硅三环具有免疫增强和抗肿瘤作用，依据药物设计的拼合原理设计了杂氮硅三环与5-氟尿嘧啶结合的协同前药，以期寻找高效低毒的抗肿瘤化合物。
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27. In this report, we try to explore the prodrug design targeting PEPT1 (oligopeptide transporter 1), and prodrug affinity towards PEPT1 as well as the uptake kinetics based on our in vitro system.
本研究的主要目的是探索基于PEPT1（寡肽转运蛋白）的前药的分子结构设计，并对前药与PEPT1载体的亲和力状况以及其在细胞内摄取的吸收动力学进行了初步探索和研究。
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28. In this report, we try to explore the prodrug design targeting PEPT1 (oligopeptide transporter 1), and prodrug affinity towards PEPT1 as well as the uptake kinetics based on our in vitro system.
本研究的主要目的是探索基于PEPT1（寡肽转运蛋白）的前药的分子结构设计，并对前药与PEPT1载体的亲和力状况以及其在细胞内摄取的吸收动力学进行了初步探索和研究。
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29. Conclusion The vector pcDNA3.1 (-) CMV·Egr -1CDglyTK may convert nonpoisonous prodrug into toxic matter which can kill CNE - 2 cells, so it can be applied in gene therapy of nasopharyngeal carcinoma.
结论pcDNA3.1(-)CMV·Egr—1CDglyTK可作为鼻咽癌基因治疗的载体。
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prodrug
