nateglinide
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释义
[医]那格列奈，那格列胺；
权威例句
Nateglinide.Repaglinide versus nateglinide monotherapy: a randomized, multicenter study
Nateglinide improves early insulin secretion and controls postprandial glucose excursions in a prediabetic population.
Pharmacokinetics of nateglinide and its metabolites in subjects with type 2 diabetes mellitus and renal failure.
Nateglinide alone and in combination with metformin improves glycemic control by reducing mealtime glucose levels in type 2 diabetes.
Rapid and short-acting mealtime insulin secretion with nateglinide controls both prandial and mean glycemia
Efficacy and safety of combination therapy: repaglinide plus metformin versus nateglinide plus metformin.
PRESERVE-beta: two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus metformin
Efficacy and tolerability of initial combination therapy with nateglinide and metformin in treatment-naive patients with type 2 diab...
Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide.
1. HPLC method for determination of L-isomer as impurity in nateglinide and its tablets was established.
建立了HPLC法测定那格列奈及其片剂中的杂质L-异构体的含量。
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2. Result:Under the experiment conditions adopted, the baseline separation of nateglinide enantiomers was obtained, with the resolution 1.68.
结果：在所建立的最佳条件下，那格列奈对映体达到基线分离，分离度为1．68。
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3. To study and evaluate the quality of Nateglinide tablets the formulation is screened.
对研制的那格列奈片进行质量评价与研究。
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4. The results indicate that nateglinide has three crystal forms, B-form, H-form and S-form.
结果表明：那格列奈具有B晶型、H晶型和S晶型三种结构。
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5. Conclustion The method can be used for the resolution and determination of the cis-isomer in nateglinide and tablet.
结论本法能有效分离测定那格列奈及片剂中顺反式异构体。
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6. To optimize the formula of the double-layer tablet of nateglinide rapid-release layer and metformin hydrochloride sustained-release layer.
优选由那格列奈速释层与盐酸二甲双胍缓释层组成的双层片处方。
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7. AIM The purpose is to establish innovational identification method of IR (eliminated method) for detection of the crystal form of nateglinide in preparations.
目的：建立一种新的红外光谱方法——消去法，以鉴别那格列奈片剂中的晶型。
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8. Considering the powerful effects of lifestyle interventions in other trials, this design feature may have reduced the magnitude of the potential benefit from nateglinide.
考虑到其它试验中生活方式干预的强大效应，本研究的设计可能已经减少了那格列奈潜在利益的幅度。
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9. Nateglinide is a novel non-sulfonylurea antidiabetic agent by stimulating insulin secretion. Its action occurs rapidly and sustains shortly.
那格列奈是一种新型的非磺酰脲类促胰岛素分泌的降糖新药，其起效快且作用时间较短。
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10. Objective:A new crystal structure being assigued as S-form was found in nateglinide. The X-ray pattern and data were given and the melting point was determined.
前言：目的：发现降糖药那格列奈另一种新的晶型结构，我们称之为S型。
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11. CE/FA is used to to determine the binding parameters of the acidic drug nateglinide and amlodipine enantiomers to protein.
实验中建立了用CE／FA测定以那格列奈为代表的酸性药物以及氨氯地平异构体与蛋白的结合参数。
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12. ABSTRACT:Objective To evaluate the efficacy and safety of nateglinide, a new antidiabetic agent, in the treatment of type 2 diabetes.
摘要：目的评价那格列奈治疗2型糖尿病的有效性和安全性。
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13. Finally, owing to its rapid-action profile, nateglinide has a relatively low risk of causing hypoglycemia.
最后，由于起效快，那格列奈造成低血糖风险相对较低。
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14. Nateglinide was detected by HPLC.
溶出度测定采用HPLC法。
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15. Conclusion:The proposed method is simple and can be used for the chiral separation of nateglinide.
结论：方法简单、快速，可作为那格列奈的手性分离方法。
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16. Objective: To establish a micellar electrokinetic chromatography (MEKC) method with the online sweeping technique to determine trace impurities in nateglinide.
利用在线推扫富集技术建立了毛细管电色谱测定新药那格列奈中痕量杂质的方法。
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17. OBJECTIVE To establish the dissolution method for nateglinide tablets.
目的：建立那格列奈片的体外溶出度的测定方法。
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18. Conclusion Nateglinide is an effective and safe drug in treating type 2 diabetes.
结论那格列奈是安全有效的降血糖药物。
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19. The feasibility of its technics is investigated according to the content changes of Nateglinide in different formulations under high temperarature, high humidity and strong light conditions.
观察高温、高湿度及光照条件下处方中主药的含量变化，判断处方的筛选结果及工艺的可行性。
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20. A new crystal structure of Nateglinide called S - out was found and determined by X - ray powder diffraction method. The pattern, data and the crystal size were given.
用X射线衍射相分析法发现并确定降血糖新药那格列奈另一种新的晶型结构，我们称之为S型。
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21. Nateglinide is safe and well tolerated with nearly no affects on the body weight of patients and rarely occurrence of hypoglycemia.
那格列奈安全性、耐受性良好，极少发生低血糖，几乎不影响病人体重。
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22. Conclusion Treatment with nateglinide in newly diagnosed T2DM, or nateglinide combined with metformin in patients with higher BMI, can reduce blood glucose level and attenuate glycemic excursion.
结论初诊2型糖尿病患者单用那格列奈，或BMI较高患者那格列奈联用二甲双胍治疗，不仅能有效降低血糖，而且能改善血糖波动。
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23. Conclusion Mitiglinide and Nateglinide have a certain inhibitory effect on oxidative stress of diabetic nephropathy patients, and has protective effect on kidney of patients, it is worth popularizing.
结论氯沙坦对糖尿病肾病患者氧化应激有一定的抑制作用，对患者的肾脏具有保护作用，值得临床关注。
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24. The formulation and technics of Nateglinide tablets are feasible in practice and its quality criteria can effectively control.
研制的那格列奈片质量可靠、工艺具有生产可行性，制订的质量标准可有效控制那格列奈片的质量。
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25. Objective To observe the therapeutic effect and safety of nateglinide combined with insulin glargine on type 2 diabetes mellitus, as compared with those of insulin Hspart 30 injection.
目的以门冬胰岛素30注射液为对照，观察那格列奈联合甘精胰岛素治疗2型糖尿病的疗效和安全性。
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26. In this work, an on -line sweeping technique for the determination of trace impurity in nateglinide by using SDS buffer solution was developed.
现场勘查中在重视物质痕迹的同时，注意认真分析、研究犯罪嫌疑人的的心理痕迹，对于确定侦查方向、缩小侦查范围具有重大意义。
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27. In this work, an on -line sweeping technique for the determination of trace impurity in nateglinide by using SDS buffer solution was developed.
现场勘查中在重视物质痕迹的同时，注意认真分析、研究犯罪嫌疑人的的心理痕迹，对于确定侦查方向、缩小侦查范围具有重大意义。
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nateglinide
